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Dendritics公司主要关注人类树突状细胞,希望找到能够促使CD34+造血前体细胞转化为树突状细胞(在GM-CSF和TNF-alpha存在的情况下)的细胞因子。在1992-2005年间,大量的研究使得研究者对人类树突状细胞的产生、细胞通路、C-type凝集素受体的功能及Toll-like受体的活性有了更深的理解。

 

DENDRITICS was started in 2005 by former members of SCHERING PLOUGH Laboratory for Immunological Research (LIR) in Dardilly, France. From their long experience at LIR, the team members of DENDRITICS have gathered complementary scientific and technological knowledge in different areas of immunology. The initial focus of LIR was in the biology of B lymphocytes, elaboration of human monoclonal antibodies, and in cytokine discovery (IL-3, IL-4, IL-7, IL-10, IL-17, GM-CSF) together with our colleagues of DNAX Research Institute in Palo Alto, California.

 

Our interest in cytokines led to the finding that human dendritic cells (DCs) could be generated in vitro from CD34+ hematopoietic progenitors cultured in the presence of GM-CSF and TNF-alpha.

 

The period from 1992 to 2005 saw the specialization of LIR in DC biology and was fuelled by a large-scale effort to discover and study the function of genes specifically expressed by these cells. This program led to a number of findings that contributed in particular to understanding the heterogeneity of DCs, the pathways regulating DC migration, the function of C-type lectin receptors in DCs and the activity of Toll-like receptors in DCs. Many novel genes were discovered through screening of cDNA libraries or through monoclonal antibodies raised against DCs.

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艾美捷科技代理Proliant Health & Biologicals品牌。

Proliant Health & Biologicals 是一家全球领先的生物技术公司,专注于为制药、生物技术、诊断和细胞治疗行业提供高质量的生物原料和定制化解决方案。公司隶属于 Proliant Inc. 集团,总部位于美国爱荷华州,拥有超过 40 年的行业经验,以其创新的产品、严格的质量控制和卓越的客户服务而闻名。Proliant提供标准级牛血清白蛋白:经济实惠;精密级牛血清白蛋白:高含量单体、超低脂肪酸含量、不含 IgG、不含蛋白酶;巯基阻断型牛血清白蛋白:阻断游离巯基基团、高含量单体白蛋白、不含 IgG 和蛋白酶。Proliant产品分类包括:

(1)生物原料供应:Proliant 提供多种高质量的生物原料,包括牛血清白蛋白(BSA)、胎牛血清(FBS)、免疫球蛋白(IgG)、转铁蛋白(Transferrin)和其他动物源性蛋白质。

(2)细胞培养基成分:Proliant 提供用于细胞培养基的关键成分,如生长因子、细胞因子和其他补充剂,支持细胞治疗、再生医学和生物制药领域的研究和生产。

(3)诊断试剂原料:公司为体外诊断(IVD)行业提供高质量的生物原料,用于开发传染病、癌症和其他疾病的诊断试剂。



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